Journal of Applied Biosciences (J. Appl. Biosci.) [ISSN 1997 - 5902]
Volume 19: 1049 - 1053. Published July 7, 2009.
Anti-inflammatory activity of alcoholic extract of Adenema hyssopifolium G.Don in acute and chronic experimental models in albino rats
R. Arivukkarasu*^, A. Rajasekaran**, S. Murugesh***
*Department of Pharmacognosy, A.K. College of Pharmacy, Krishnankoil-626 190, India; **Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore, India; ***Department of Biotechnology, Shanmugha Arts, Science, Technology & Research Academy, SASTRA University, Thanjavur-613 402.
^Corresponding author e–mail:rsekaran2001in@yahoo.co.in
ABSTRACT
Objective: To evaluate the anti-inflammatory effect of alcoholic extract of Adenema hyssopifolium.
Methodology and results: Carrageen induced rat paw edema method (acute), Turpentine oil induced granuloma pouch (sub acute) and formalin induced rat hind paw edema (chronic) models in rats was adopted for the study. The alcohol extract (using 90%) at a concentration of 300 and 600 mg kg-1 p.o., and its ethyl acetate fractions at 25 and 50 mg kg-1 p.o. showed a significant dose dependent anti-inflammatory activity in carrageen induced rat hind paw edema as well as formalin induced rat hind paw edema chronic model in rats. In the chronic model, Adenema hyssopifolium alcoholic extract HAE 600 mg kg-1), ethyl acetate fraction (50 mg kg-1) and the standard drug showed 55.5, 63.4 and 68.0 % (p < 0.001) inhibitions, respectively.
Conclusion and application of findings: The alcohol extract of A. hyssopifolium exhibited anti-inflammatory activity in all the tested models. The findings justify current utilization of alcoholic extract of Adenema hyssopifolium.
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