Journal of Applied Biosciences (J. Appl. Biosci.) [ISSN 1997 - 5902]
Volume 28: 1718 - 1730. Published April 8, 2010.
Antihyperglycemic and antihyperlipidemic effects of extracts of the pulp of Syzygium cuminiand bark of Cinnamon zeylanicum in streptozotocin-induced diabetic rats
* Rekha. N, Balaji. R and Deecaraman.M
*Department of Industrial biotechnology, Dr.MGR Educational & Research Institute, Maduravoyal,
Chennai-600095, TamilNadu, India. Telephone: +91-044- 23782176 / 23782186 / 23782085 Fax -23783165
ABSTRACT
Objective: The antidiabetic effect of the aqueous extract of the pulp of Jamun (Syzygium cumini) and the bark of Cinnamon (Cinnamon zeylanicum) in single and composite way was studied for managing streptozotocin-induced diabetes mellitus in rats.
Methodology and results: Hyperglycemia was induced by a single intraperitoneal injection of streptozotocin, which significantly elevated the blood glucose levels, decreased the serum insulin levels and decreased the body weight of diabetic rats when compared to that of normal control. Administration of the composite extract in diabetic rats resulted in a significant reduction on blood glucose levels. In addition, it significantly recovered serum insulin levels and prevented the decrease in body weight than a single administration of the extract. Hyperlipidemia, marked increase in lipid peroxide levels and concomitant decrease in antioxidant enzymes was observed in untreated diabetic rats. Treatment with composite extracts significantly reversed these conditions to near normal levels than single administration of extracts.
Conclusions and application of findings: These above results justify the use of a combination of aqueous extracts of pulp of Syzygium cumini and bark of Cinnamon zeylanicum for the remedial effects against streptozotocin induced diabetic state.
Key words: Hyperglycemia, Composite, Insulin, Hyperlipidemia, lipid peroxides.
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