Journal of Applied Biosciences (J. Appl. Biosci.) [ISSN 1997 - 5902]
Volume 56: 4097 - 4107. Published August, 2012.
*Odhiambo F., Chek J.B.L and Moro
J.O.
Department of Biochemistry, University of Nairobi,
P.O Box 30197-00100, Nairobi, Kenya.Corresponding
author: Odhiambo
Felix Blair, email address: bfelixo@yahoo.com
RESUME
Introduction: Barbiturates and carbon tetrachloride (CCL4)
are known to have effects on liver enzymes. More ever, barbiturates
which are used as sedative hypnotics, anticonvulsants, generally
cause induction of liver microsomal enzymes while CCL4 cause
hepatoxity releasing various liver enzymes.
Objective: To
determine the effects of Phenobarbital and carbon tetrachloride on some
selected liver enzymes.
Methodology and results: Rats treated with Phenobarbital
had higher levels of activity of transaminases, alkaline phosphatase and longer
to gain writing reflex while CCl4 treated rats had reduced levels of the
mentioned enzyme and shorter time to gain writing reflex .
Conclusion and application: Treatment with Phenobarbital needs continuous
adjustment and regulation of dosage by the attending clinician. A history of
the patient is required before administration of other drugs or carrying a
therapeutic drug monitoring to confirm toxicology. It was therefore concluded
that barbiturates
are inducers of liver enzymes while CCl4 is a liver toxicant
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