The objective of this study was to use Radix astragali as an alternative growth medium for cultivation of Ganoderma lucidum and to investigate anti-fatigue activity of its fermentationproduct. The results suggested that the growth of mycelial of G. lucidum can be inhibited when using Radix astragali as a substrate, but the extracellular polysaccharide in the fermentationproduction of G. lucidum increased significantly compared to that of general medium. Different doses of its product lengthened significantly the exhaustive swimming time, increased the contents of hepatic glycogen, and reduced significantly the levels of serum ureanitrogen (SUN) in blood compared to the control. However, the accumulation of blood lactic acid (BLA) or accelerate the clearance of BLA in the group which was administrated with the extract of submerged fermentation of G. lucidum using Radix astragali as substrate (GR) were significantly inhibited compared to the control. These results suggested that the extract of submerged fermentation of G. lucidum using Radix astragali as substrate might significantly alleviate physical fatigue of the mice in vivo.  

Key words

Anti-fatigue activity; Ganderma lucidum; Radix astragali; submerged fermentation

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